ACT Fire & Rescue (ACTF&R) have contained the house fire on Sellwood Street, Holt.
ACTF&R responded with three pumpers, a breathing apparatus vehicle and a commander.
Due to the extensive damage and long operation, firefighters will remain on scene to investigate further in the morning.
ACT Ambulance Service (ACTAS) have transported one person to hospital with smoke inhalation.
The cause of the fire is yet to be determined.
The community is asked to avoid the area where possible.